How Unruly DNA Loops Are Shaping Cancer—and Treatments

Extrachromosomal DNA has emerged as a key driver of cancer evolution, with recent studies showing it is widespread, highly adaptable, and targetable for treatment. Vulnerabilities created by ecDNA-driven molecular processes are now being exploited in a first clinical test of whether these rogue genetic loops can be drugged for therapeutic gain.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-nw2025-0025
Primary Topic
DNA and Nucleic Acid Chemistry
Type
article
Field-Weighted Citation Impact
0.00
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article

How Unruly DNA Loops Are Shaping Cancer—and Treatments

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Cancer Discovery
DNA and Nucleic Acid Chemistry
article

How Unruly DNA Loops Are Shaping Cancer—and Treatments

article en

Abstract

Extrachromosomal DNA has emerged as a key driver of cancer evolution, with recent studies showing it is widespread, highly adaptable, and targetable for treatment. Vulnerabilities created by ecDNA-driven molecular processes are now being exploited in a first clinical test of whether these rogue genetic loops can be drugged for therapeutic gain.

Cancer Discovery
Openalex Percentile: Top 95%
DNA and Nucleic Acid Chemistry
DOISourceOpenAlex
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How Unruly DNA Loops Are Shaping Cancer—and Treatments · Cancer Discovery (2025) | TGRS Research Map | TGRS