Muscle MRI quantifies disease progression in amyotrophic lateral sclerosis
Our findings demonstrate the effectiveness of muscle MRI as a sensitive neuroimaging biomarker of disease progression in ALS, highlighting its potential application in clinical trials.
Authors
- Christian Našel (ORCID: https://orcid.org/0000-0002-1418-7924)
- Christopher D. J. Sinclair (ORCID: https://orcid.org/0000-0002-4176-9479)
- Linda Greensmith
- Jodie Allen
- John S. Thornton (ORCID: https://orcid.org/0000-0003-3248-8437)
- Luca Zampedri (ORCID: https://orcid.org/0000-0002-4242-8641)
- Karin Trimmel (ORCID: https://orcid.org/0000-0002-9203-5344)
- Oliver J. Ziff (ORCID: https://orcid.org/0000-0002-1504-7245)
- Jasper M. Morrow (ORCID: https://orcid.org/0000-0001-6879-8539)
- Andrea Malaspina (ORCID: https://orcid.org/0000-0002-8020-7567)
- Stephen Wastling (ORCID: https://orcid.org/0000-0003-4648-9932)
- Tarek Yousry (ORCID: https://orcid.org/0000-0003-3295-0628)
- Nikhil Sharma (ORCID: https://orcid.org/0000-0001-8903-2938)
- Robin Howard (ORCID: https://orcid.org/0000-0001-7021-714X)
- Sachit Shah
- Katie Sidle
- Nick Zafeiropoulos
- Magdalena Dudziec
- Uros Klickovic
Institutions
- Universitätsklinikum Tulln (AT)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1136/jnnp-2024-335571
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Target ALS
- Brain Research Trust
- Motor Neurone Disease Association
- Medical Research Council