Mycoplasma genitalium protein of adhesion inhibits human urethral epithelial cells apoptosis via CypA/PI3K/AKT/mTOR-dependent autophagy
This study demonstrates that rMgPa suppresses apoptosis in SV-HUC-1 cells by inducing autophagy via CypA-mediated modulation of the PI3K/AKT/mTOR pathway, which elucidates a novel survival strategy employed by <i>M. genitalium</i> within host cells and provides valuable insights for potential therapeutic interventions targeting <i>M. genitalium</i> infections.
Authors
- Siqi Gao (ORCID: https://orcid.org/0000-0002-9477-4298)
- Yanhua Zeng (ORCID: https://orcid.org/0000-0002-1820-746X)
- Hua Xiao (ORCID: https://orcid.org/0000-0002-4201-7842)
- Zhijia Huang (ORCID: https://orcid.org/0000-0002-6639-7990)
- Li Chen (ORCID: https://orcid.org/0000-0002-4552-4401)
- Zhuo Zeng (ORCID: https://orcid.org/0000-0003-4875-2909)
- Haodang Luo (ORCID: https://orcid.org/0000-0001-9283-1052)
- Dan Luo (ORCID: https://orcid.org/0000-0003-2838-2832)
- Xiaoqian Tang
Institutions
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fmicb.2025.1570659
- Citations
- 1
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81