Multiomic traits reveal that critical irinotecan-related core regulator FSTL3 promotes CRC progression and affects ferroptosis
We confirmed that irinotecan-related regulators, especially FSTL3, have effective prognostic value in CRC and speculated that FSTL3 may promote CRC progression and affect ferroptosis, which is beneficial for identifying candidate targeted irinotecan-related regulators and accurate individualized treatment strategies for CRC.
Authors
- Bufu Tang (ORCID: https://orcid.org/0000-0003-3525-4433)
- Cheng-Yi Huang (ORCID: https://orcid.org/0000-0001-6686-5750)
- Huojun Zhang
- Minghua Bai
- Wenjuan Chen (ORCID: https://orcid.org/0000-0003-4361-980X)
- Jinggang Chen
Institutions
- Sun Yat-sen University (CN)
- Second Military Medical University (CN)
- Fudan University (CN)
- Zhejiang Cancer Hospital (CN)
- Changhai Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12935-025-03753-7
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59