Streptomyces sp. VITGV156 secondary metabolite binds pathogenic protein PBP2a and Beta-lactamase
The genomic and bioactive analysis of <i>Streptomyces</i> sp. VITGV156 highlights its potential as a valuable source of novel antimicrobial agents. The identification of unique biosynthetic genes and bioactive secondary metabolites suggests its possible application in combating multidrug-resistant pathogens. Further studies, including purification and in vivo testing, are necessary to validate these findings and explore their therapeutic potential.
Authors
- Manisha R. Shah (ORCID: https://orcid.org/0000-0002-0704-9224)
- K. Deepasree
- Subhashree Venugopal (ORCID: https://orcid.org/0000-0001-7713-5737)
- Antony V. Samrot (ORCID: https://orcid.org/0000-0001-9536-0567)
- J. Godwin Christopher (ORCID: https://orcid.org/0000-0002-9328-983X)
- K. Ramanathan (ORCID: https://orcid.org/0000-0002-1613-0729)
- Sivakumar Arumugam (ORCID: https://orcid.org/0000-0001-8834-8834)
- Muthu Kumar Thirunavukkarasu (ORCID: https://orcid.org/0000-0001-8021-222X)
- Veilumuthu Pattapulavar
- Sathiyabama Ramanujam
Institutions
- Manipal University College Malaysia (MY)
- Karpagam Academy of Higher Education (IN)
- Vellore Institute of Technology University (IN)
Publication Details
- Journal
- Frontiers in Bioinformatics
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fbinf.2025.1544800
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39