Therapeutic mucosal vaccination of herpes simplex virus type 2 infected guinea pigs with an adenovirus-based vaccine expressing the ribonucleotide reductase 2 and glycoprotein D induces local tissue-resident CD4+ and CD8+ TRM cells associated with pr
Taken together, these preclinical results provide new insights into the T cell mechanisms of protection against recurrent genital herpes and confirm the tegument RR2 protein and glycoprotein D as viable candidate antigens to be incorporated in future genital herpes therapeutic vaccines.
Authors
- Hawa Vahed (ORCID: https://orcid.org/0000-0002-5753-5378)
- Swena Patel
- Lbachir BenMohamed (ORCID: https://orcid.org/0000-0001-9468-2521)
- Miyo Sun
- Swayam Prakash (ORCID: https://orcid.org/0000-0002-3348-2427)
- Afshana Quadiri (ORCID: https://orcid.org/0000-0003-0212-5854)
- Kathy Hormi–Carver
- Jimmy Tadros
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1568258
- Citations
- 4
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Research to Prevent Blindness
- National Eye Institute
- National Institute of Allergy and Infectious Diseases