Strategy for drug repurposing in fibroadipogenic replacement during muscle wasting: application to duchenne muscular dystrophy
We present a map of molecular targets of approved drugs that helps in predicting which therapeutic option may affect FAP differentiation. This method allows to study the potential effect of signalling circuits on FAP differentiation after drug treatment providing insights into molecular mechanism of action of muscle degeneration. The accuracy of the method is demonstrated by comparing the signal pathway activity obtained after drug treatment with proteomic and genomic data from patient-derived cells.
Authors
- Vellia Justian
- Zoe Laidler
- Xavier Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-5314-6607)
- Esther Fernández‐Simón (ORCID: https://orcid.org/0000-0003-4804-6553)
- Dan Cox (ORCID: https://orcid.org/0000-0002-5405-6267)
- Ana Carrasco‐Rozas (ORCID: https://orcid.org/0000-0003-2165-8162)
- Andrew Bowey
- Priyanka Mehra
- Paul R. P. Rushton (ORCID: https://orcid.org/0000-0002-3387-9416)
- Jordi Díaz‐Manera (ORCID: https://orcid.org/0000-0003-2941-7988)
- Patricia Piñol‐Jurado
- I. Matthews
- Susana López‐Fernández
Institutions
- Universitat Autònoma de Barcelona (ES)
- Royal Veterinary College (GB)
- Royal Victoria Infirmary (GB)
- Hospital de Sant Pau (ES)
- Great North Children's Hospital (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fcell.2025.1505697
- Citations
- 1
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81