The effect of 1,25(OH)2D3 on Dickkopf-1 methylation in colorectal cancer
DKK1 functions as a tumour suppressor in colorectal cancer, and 1,25(OH)<sub>2</sub>D<sub>3</sub> upregulates DKK1 expression by inducing demethylation of the DKK1 promoter and 5'UTR in specific colorectal cancer cell lines.
Authors
- Qianying Hu (ORCID: https://orcid.org/0000-0001-5902-6457)
- Zilong Zhou (ORCID: https://orcid.org/0009-0006-9170-8689)
- Xianling Cong (ORCID: https://orcid.org/0000-0002-5790-4188)
- Hongyan Sun (ORCID: https://orcid.org/0000-0003-0140-6785)
- Nan Li (ORCID: https://orcid.org/0000-0002-8248-9027)
- Yue Hu (ORCID: https://orcid.org/0000-0002-1812-2642)
- Liehao Yang
Institutions
- Union Hospital (HK)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13148-025-01857-5
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.42