Combined analysis of single-cell and bulk transcriptome sequencing data identifies critical glycolysis genes in idiopathic pulmonary arterial hypertension
Our study identifies IGF1, KARS, CASP3, and CDKN2A as key regulatory genes in glycolysis in IPAH, which provides the basis for the development of targeted therapies.
Authors
- Yongbing Wang (ORCID: https://orcid.org/0000-0001-8973-8041)
- Na Sun (ORCID: https://orcid.org/0000-0001-9936-6907)
- Zixuan Wu (ORCID: https://orcid.org/0000-0002-2993-9949)
- Youli Fan
- Ruyi Jia
- Xuan Gao
- Jiangwei Song
- Lei Gao (ORCID: https://orcid.org/0009-0006-9787-3896)
- Bingxiang Wu (ORCID: https://orcid.org/0000-0002-8524-1086)
- Yihao Zhang (ORCID: https://orcid.org/0000-0002-1581-5937)
- Jing Huang (ORCID: https://orcid.org/0000-0002-1755-5008)
- Huiyu He (ORCID: https://orcid.org/0009-0000-8419-5025)
- Ruzhi Deng (ORCID: https://orcid.org/0000-0002-4587-7223)
- Guanying Wang (ORCID: https://orcid.org/0000-0001-8322-4584)
- Jiangjiang Xu
- Binfeng Sun
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Harbin Engineering University (CN)
- Harbin Medical University (CN)
- Heilongjiang University of Chinese Medicine (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12967-025-06373-x
- Citations
- 5
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China