The transcriptional repressor Ctbp2 as a metabolite sensor regulating cardiomyocytes proliferation and heart regeneration
In conclusion, this study demonstrates that the Ctbp2-FoxO1-p21/p27 axis can promote cardiomyocyte proliferation and heart regeneration. As a metabolite sensor, Ctbp2 is activated during cardiomyocyte ischemia and hypoxia, while it is inactivated under normal conditions. This controllable and transient regulation of cardiomyocyte proliferation can avoid the detrimental effects on cardiac function caused by long-term regulation of cardiomyocyte proliferation, such as hypertrophic cardiomyopathy or heart failure. This provides new targets and new ideas for addressing the issues of cardiomyocyte proliferation and heart regeneration.
Authors
- Wenkang Jiang
- Hulun Li (ORCID: https://orcid.org/0000-0003-2501-6861)
- Yongtai Liu (ORCID: https://orcid.org/0000-0002-4550-7070)
- Wei Huang (ORCID: https://orcid.org/0000-0002-7399-8006)
- Xiujuan Lang (ORCID: https://orcid.org/0009-0007-1790-0266)
- Xijun Liu (ORCID: https://orcid.org/0000-0002-2624-6901)
- Jianwen Ding (ORCID: https://orcid.org/0000-0003-3526-3380)
- Yanping Wang (ORCID: https://orcid.org/0000-0002-9091-0125)
- Jing Wang (ORCID: https://orcid.org/0000-0002-6326-4869)
- Jiayi Li (ORCID: https://orcid.org/0000-0001-8007-4138)
- Bo Sun (ORCID: https://orcid.org/0000-0001-7830-132X)
- Sifan Zhang (ORCID: https://orcid.org/0000-0002-6086-9678)
- Yanting Meng
Institutions
- Harbin Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s10020-025-01168-8
- Citations
- 2
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China