Somatic Copy Number Alterations in Circulating Cell-Free DNA as a Prognostic Biomarker for Hepatocellular Carcinoma: Insights from a Proof-of-Concept Study
Our results suggest that the analysis of TF by sWGS is a promising non-invasive tool for the identification of HCC with aggressive clinical behavior, whereas it is not sensitive enough for early HCC detection. This molecular assay can improve prognostic stratification in HCC patients.
Authors
- Fabio Farinati (ORCID: https://orcid.org/0000-0002-2944-1374)
- Patrizia Burra (ORCID: https://orcid.org/0000-0002-8791-191X)
- Stefano Indraccolo (ORCID: https://orcid.org/0000-0002-4810-7136)
- Francesco Paolo Russo (ORCID: https://orcid.org/0000-0003-4127-8941)
- Elisabetta Lazzarini (ORCID: https://orcid.org/0000-0002-7284-999X)
- Valeria Tosello (ORCID: https://orcid.org/0000-0001-9560-340X)
- Paola Zanaga (ORCID: https://orcid.org/0000-0001-7193-4335)
- Lory Santarelli (ORCID: https://orcid.org/0000-0003-1015-7098)
- Filippo Pelizzaro (ORCID: https://orcid.org/0000-0003-0584-1442)
- Elisa Pinto (ORCID: https://orcid.org/0000-0002-5658-942X)
- D. Boscarino (ORCID: https://orcid.org/0009-0003-5774-1723)
- Chiara Romualdi (ORCID: https://orcid.org/0000-0003-4792-9047)
- Martina Gambato (ORCID: https://orcid.org/0000-0002-0101-1938)
- Sara Potente
- R. Cardin
- Teresa Zappitelli
Institutions
- University of Padua (IT)
- Istituto Oncologico Veneto (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Ab Analitica (Italy) (IT)
Publication Details
- Journal
- Cancers
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3390/cancers17071115
- Citations
- 3
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.81