Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts
We found that genetic liability to sedentary behaviour is associated with incident CVD, although effect sizes with current PGS remained small. These findings suggest that genetic liability to sedentary behaviour is an under-recognised driver of common CVDs.
Authors
- Niko Paavo Tynkkynen (ORCID: https://orcid.org/0000-0001-8245-1275)
- Jaakko A. Kaprio (ORCID: https://orcid.org/0000-0002-3716-2455)
- Elina Sillanpää (ORCID: https://orcid.org/0000-0001-6375-959X)
- Ulrik Wisløff (ORCID: https://orcid.org/0000-0002-7211-3587)
- Karsten Øvretveit (ORCID: https://orcid.org/0000-0002-5528-0674)
- Laura Joensuu (ORCID: https://orcid.org/0000-0002-9544-6552)
- Teemu Palviainen (ORCID: https://orcid.org/0000-0002-7847-8384)
- Ulf Ekelund (ORCID: https://orcid.org/0000-0003-2115-9267)
- Kaisa Koivunen (ORCID: https://orcid.org/0000-0002-0710-0069)
- Anja Bye (ORCID: https://orcid.org/0000-0003-1259-5542)
- Marie Klevjer (ORCID: https://orcid.org/0000-0001-8372-276X)
Institutions
- Norwegian Institute of Public Health (NO)
- University of Helsinki (FI)
- Norwegian University of Science and Technology (NO)
- St Olav's University Hospital (NO)
- Institute for Molecular Medicine Finland (FI)
- Central Finland Health Care District (FI)
- Norwegian School of Sport Sciences (NO)
- University of Jyväskylä (FI)
Publication Details
- Journal
- British Journal of Sports Medicine
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1136/bjsports-2024-109491
- Citations
- 5
- Primary Topic
- Obesity, Physical Activity, Diet
- Type
- article
- Field-Weighted Citation Impact
- 9.39
Funders
- Broad Institute
- Academy of Finland
- Päivikki ja Sakari Sohlbergin Säätiö