Fibroblast Growth Factor 21 Levels Are Associated With Perception and Neural Responses to Sweetness in Type 2 Diabetes Mellitus
FGF21 levels were independently associated with changes in sweet taste perception and preference in T2DM patients and were significantly associated with activation in reward-related brain regions. This study reveals the potential role of FGF21 in regulating responses to sweet foods in T2DM and provides insight to develop new therapeutic strategies for diabetes.
Authors
- Anran Chen
- Weiping Jia (ORCID: https://orcid.org/0000-0002-6244-2168)
- Di Cheng (ORCID: https://orcid.org/0000-0001-9388-376X)
- Silin Liu (ORCID: https://orcid.org/0000-0001-7406-4179)
- Huating Li (ORCID: https://orcid.org/0000-0003-0526-5545)
- Qian Wu (ORCID: https://orcid.org/0000-0002-2292-4816)
- Dian Zeng (ORCID: https://orcid.org/0000-0002-5592-9584)
- Jingyi Guo (ORCID: https://orcid.org/0000-0001-8857-2254)
- Rui Han (ORCID: https://orcid.org/0000-0001-6358-4689)
- Qichen Fang (ORCID: https://orcid.org/0000-0002-3805-4050)
- Qinyi Wang (ORCID: https://orcid.org/0009-0009-6747-4036)
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
- Shilin Liu (ORCID: https://orcid.org/0000-0002-3704-3798)
- Piao Kang
- Yuehua Li (ORCID: https://orcid.org/0000-0001-8028-248X)
- Jiacheng Ni
- Yu-Wei Lu (ORCID: https://orcid.org/0000-0002-3461-2238)
- Xiaomeng Wu (ORCID: https://orcid.org/0000-0002-1422-3040)
- Liang Wu (ORCID: https://orcid.org/0000-0002-8241-2433)
- Wenli Ge
- Ying Zhang (ORCID: https://orcid.org/0000-0003-3288-0041)
- Lifei Ma
- Shujie Yu (ORCID: https://orcid.org/0000-0003-3548-6170)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-03-26
- DOI
- https://doi.org/10.4093/dmj.2024.0390
- Citations
- 1
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81