Criterios clínicos y bioquímicos del síndrome metabólico asociados a niveles de alanina aminotransferasa en una muestra pediátrica con sobrepeso y obesidad en Lima-Perú: Estudio transversal de un solo centro, 2015-2019

Objective: To determine the association between clinical/biochemical criteria of metabolic syndrome and alanine aminotransferase (alt) levels in patients attended in the Endocrinology and Metabolism service of the Instituto Nacional de Salud del Niño between January 2015 and December 2019. Materials and methods: An analytical, retrospective cross-sectional study based on medical records of patients between 10 and 18 years of age with overweight or obesity. Bivariate and multivariate statistics were used to determine the associations between overweight groups and ALT levels. Results: A 39.3% of the sample presented high ALT levels. However, ALT levels were higher in the group of patients with obesity (42.4%). Only patients with obesity and high ALT levels showed increased total cholesterol and LDL (p < 0.05). According to the multivariate model, high LDL would function as a predictor of high ALT in overweight pubescent and adolescent patients (PR = 1.89; 95 % CI: 1.16 - 3.10). Conclusions: High LDL was associated with high ALT levels, which could be an indicator of cardiovascular disease, probably due to liver involvement. Further longitudinal studies are still required to establish causal associations.