Complementary role of transcriptomic endotyping and protein-based biomarkers for risk stratification in sepsis-associated acute kidney injury
Combining transcriptomic endotyping with protein-based biomarker profiling enhances risk-stratification in SA-AKI, offering a promising strategy for personalized treatment and trial enrichment in the future. Further research should validate these findings and explore therapeutic applications.
Authors
- Christian Morath (ORCID: https://orcid.org/0000-0003-2218-7817)
- Bengi S. Tavris (ORCID: https://orcid.org/0000-0002-1901-4555)
- Florian Uhle (ORCID: https://orcid.org/0000-0001-8876-7430)
- Thorsten Brenner (ORCID: https://orcid.org/0000-0002-4570-877X)
- Simon Dubler (ORCID: https://orcid.org/0000-0003-0886-595X)
- Roman Szudarek
- Mascha O. Fiedler (ORCID: https://orcid.org/0000-0002-0127-2783)
- Felix C. F. Schmitt (ORCID: https://orcid.org/0000-0001-6464-6191)
- Oliver Liesenfeld (ORCID: https://orcid.org/0000-0002-4348-5509)
- Martin Zeier
- Timothy E. Sweeney (ORCID: https://orcid.org/0000-0002-3596-1093)
- Christian Nußhag (ORCID: https://orcid.org/0000-0001-7776-3784)
- Markus Weigand (ORCID: https://orcid.org/0000-0002-0325-2268)
- Christoph Rupp
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Atotech (Germany) (DE)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Critical Care
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13054-025-05361-3
- Citations
- 6
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 8.58
Funders
- Universitätsklinikum Heidelberg
- Medizinischen Fakultät Heidelberg, Universität Heidelberg