Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation
The present study underscores the regulatory role of circulating EV-delivered miR-133a-3p in modulating PANoptosis through ELAVL1-mediated NLRP3 mRNA stabilization. This mechanism represents a potential therapeutic target for attenuating myocardial injury by suppressing PANoptosis.
Authors
- Lu Jiang (ORCID: https://orcid.org/0000-0001-6003-7575)
- Ke Liu (ORCID: https://orcid.org/0000-0002-3960-1124)
- Zheng Dai
- Deliang Wang (ORCID: https://orcid.org/0009-0008-6488-0234)
Institutions
- University of Electronic Science and Technology of China (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13062-025-00605-2
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42