Diagnosis of celiac disease on a gluten-free diet: a multicenter prospective quasi-experimental clinical study
The percentage of TCRγδ<sup>+</sup> IELs and the analysis of IL-2 levels and gut-homing CD8<sup>+</sup> T cells are promising diagnostic methods for CD on a GFD. Notably, our results suggest that the CD8<sup>+</sup> T-cell assay may provide a consistent and reliable alternative to the extended GC, eliminating the need for invasive procedures to obtain duodenal samples and prolonged gluten ingestion. However, further research with larger cohorts are necessary to validate these findings and establish their definitive clinical utility.
Authors
- Ángela Ruiz‐Carnicer (ORCID: https://orcid.org/0000-0002-7100-846X)
- Fernando Fernández‐Bañares (ORCID: https://orcid.org/0000-0002-1489-504X)
- Carla Senosiain
- Natalia López‐Palacios
- Sergio Farráis (ORCID: https://orcid.org/0000-0002-8772-4225)
- Sara Gómez-Aguililla (ORCID: https://orcid.org/0000-0002-7525-1408)
- Eva Tristán (ORCID: https://orcid.org/0000-0002-9317-2447)
- Bárbara P. González‐García (ORCID: https://orcid.org/0000-0002-9287-6047)
- Nora Fernández‐Jiménez (ORCID: https://orcid.org/0000-0001-6307-0880)
- Ana Montero‐Calle (ORCID: https://orcid.org/0000-0001-5141-0454)
- María Corzo
- Mar Pujals (ORCID: https://orcid.org/0000-0002-8512-2853)
- Jorge Infante‐Menéndez (ORCID: https://orcid.org/0000-0003-0303-6538)
- Beatriz Arau (ORCID: https://orcid.org/0000-0003-4099-505X)
- Garbiñe Roy (ORCID: https://orcid.org/0000-0001-6124-7574)
- María Garranzo‐Asensio (ORCID: https://orcid.org/0000-0003-0850-4986)
- Juana María Jiménez Hernández
- Isabel Casado
- Carolina Sousa (ORCID: https://orcid.org/0000-0002-9235-9496)
Institutions
- University of the Basque Country (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Clínico San Carlos (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Unidad de Investigación en cuidados y servicios de salud (Investén-isciii) (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Mútua Terrassa (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Universidad Autónoma de Madrid (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12916-025-04008-y
- Citations
- 12
- Primary Topic
- Celiac Disease Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 21.73
Funders
- Ministerio de Ciencia e Innovación
- Osasun Saila, Eusko Jaurlaritzako
- Departament de Salut, Generalitat de Catalunya