Ectopic expression of Slc1a2 in the prefrontal cortex of sleep-deprived male mice counteracts the glutamate/GABA-glutamine dysfunction
Slc1a2 ectopic expression in the PFC negates SD-induced GABA dysfunction through vital AC-Neu communication. This study sheds light on the mechanisms through which SD affects neural function and suggesting potential treatments for sleep-related disorders.
Authors
- Li Xuan (ORCID: https://orcid.org/0000-0002-6176-7411)
- Guangqi Song (ORCID: https://orcid.org/0000-0002-2409-0771)
- Keyan Chen (ORCID: https://orcid.org/0000-0002-8041-4312)
- Bo Ouyang (ORCID: https://orcid.org/0000-0003-2153-7803)
- Hongying Wang (ORCID: https://orcid.org/0000-0003-2390-7564)
- Pan Zhao (ORCID: https://orcid.org/0000-0001-7579-9783)
- Min Li (ORCID: https://orcid.org/0000-0002-6006-604X)
- Ping Zhang (ORCID: https://orcid.org/0000-0001-6831-1807)
- Fengying Zhang (ORCID: https://orcid.org/0000-0003-1270-207X)
- Li Jiang (ORCID: https://orcid.org/0000-0002-4422-567X)
- Yingbin Wang (ORCID: https://orcid.org/0000-0001-8575-065X)
- Li Yao (ORCID: https://orcid.org/0000-0002-7785-5563)
- Tang Yong-hong
- Xingyuan Quan (ORCID: https://orcid.org/0000-0003-4627-3621)
Institutions
- Central Hospital Affiliated to Shenyang Medical College (CN)
- Jinzhou Medical University (CN)
- China Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12915-025-02161-7
- Citations
- 2
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86