Cancer incidence inconsistency between UK Biobank participants and the population: a prospective cohort study
The overall cancer incidence was 10% lower for the UK Biobank participants compared with the population, with most cancers having a lower incidence that increased with deprivation. Irrespective of their causes, the inconsistencies could bias UK Biobank research results related to absolute cancer risks, such as the development and/or validation of cancer risk models and penetrance estimates for cancer susceptibility genes.
Authors
- John L. Hopper (ORCID: https://orcid.org/0000-0002-8567-173X)
- Tuong L. Nguyen (ORCID: https://orcid.org/0000-0002-6597-8363)
- Gillian S. Dite (ORCID: https://orcid.org/0000-0002-2448-2548)
- Shuai Li (ORCID: https://orcid.org/0000-0002-8696-8594)
- Chenxi Li (ORCID: https://orcid.org/0000-0001-9660-9256)
Institutions
- The University of Sydney (AU)
- The University of Melbourne (AU)
- Children's Hospital at Westmead (AU)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12916-025-03998-z
- Citations
- 4
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.27
Funders
- National Health and Medical Research Council