LincRNA-ASAO promotes dental pulp repair through interacting with PTBP1 to increase ALPL alternative splicing
We have identified the novel lincRNA-ASAO, which can promote the odontoblast differentiation of hDPSCs. The mechanism study found that lincRNA-ASAO/PTBP1 mediated the exon 2 skipping of ALPL pre-mRNA, resulting in the type 2 splice variant of ALPL. Our results enrich the understanding of lncRNAs and alternative splicing in regulating the odontoblast differentiation of hDPSCs, and provide clues to improve the clinical therapeutic potential of hDPSCs for dental pulp restoration.
Authors
- Louis T. Dang (ORCID: https://orcid.org/0000-0003-4853-4952)
- Wei Qiu (ORCID: https://orcid.org/0000-0002-5548-5629)
- Fuchun Fang (ORCID: https://orcid.org/0000-0002-0090-8073)
- Lu Chen (ORCID: https://orcid.org/0000-0001-9347-291X)
- Sitong Liu (ORCID: https://orcid.org/0000-0001-7355-1549)
- Jiahao Lin
- Yumeng Yang (ORCID: https://orcid.org/0000-0002-8011-6593)
- Chen Zhao (ORCID: https://orcid.org/0000-0001-8892-5689)
- Zehao Chen (ORCID: https://orcid.org/0000-0001-9947-7906)
- Xiaolan Guo (ORCID: https://orcid.org/0000-0003-4591-0676)
Institutions
- Nanfang Hospital (CN)
- Stomatology Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13287-025-04274-w
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China