Aspartame increases the risk of liver cancer through CASP1 protein: A comprehensive network analysis insights
This study identifies CASP1 as a potential target for aspartame-induced liver cancer, which is of a significant public health importance. The potential carcinogenic risk of aspartame and reliability need to be re-evaluated. The study provides a new method for assessing the safety of food additives and offers novel scientific insights into the toxicological effects of aspartame. Furthermore, subsequent experimental validation is crucial for further research into the carcinogenic mechanisms of aspartame.
Authors
- W. Li (ORCID: https://orcid.org/0009-0007-9273-3621)
- N. Li
- Yixuan Zeng
- Bing Deng (ORCID: https://orcid.org/0009-0009-0830-4686)
- Yufeng Gu (ORCID: https://orcid.org/0000-0003-1196-6997)
- Yi Liu (ORCID: https://orcid.org/0000-0002-2051-440X)
- Peng Xie (ORCID: https://orcid.org/0000-0002-4763-7207)
- S W Lu
Institutions
- Hunan University of Science and Technology (CN)
- TCM-Intigrated Cancer Center of Southern Medical University (CN)
- Jiangmen Central Hospital (CN)
- Hunan University of Technology (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.118089
- Citations
- 17
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 23.02