Diagnostic performance of plasma p-tau217 in a memory clinic cohort using the Lumipulse automated platform
Plasma p-tau217 shows excellent results for detecting amyloid pathology at brain level in a clinical setting with an AUC of 0.95. It is a highly specific marker of AD and increases progressively along the disease continuum. Using plasma p-tau217 as an initial diagnostic tool with cut-offs at sensitivities and specificities of 95 or 97.5% could save between 57.4-84.8% of LP/PETs with diagnostic accuracies of 95-97%. Plasma NfL increases progressively at different cognitive stages.
Authors
- Marta Drake-Pérez (ORCID: https://orcid.org/0000-0002-4049-2885)
- Eloy Rodríguez‐Rodríguez (ORCID: https://orcid.org/0000-0001-7742-677X)
- Juan Irure‐Ventura (ORCID: https://orcid.org/0000-0003-2315-8671)
- Maria Teresa Garcı́a-Unzueta (ORCID: https://orcid.org/0000-0003-2531-3284)
- Marcos López‐Hoyos (ORCID: https://orcid.org/0000-0003-0562-427X)
- Francisco Martínez‐Dubarbie (ORCID: https://orcid.org/0000-0002-1482-7813)
- María Mercedes Bravo (ORCID: https://orcid.org/0000-0002-6472-8362)
- Sara López‐García (ORCID: https://orcid.org/0000-0002-7888-8850)
- Carmen Lage (ORCID: https://orcid.org/0000-0003-1703-121X)
- Pascual Sánchez‐Juan
- Andrea Corrales‐Pardo
- María Rivera‐Sánchez
- Enrique Marco de Lucas (ORCID: https://orcid.org/0000-0002-5310-7245)
- Marta Fernández‐Matarrubia (ORCID: https://orcid.org/0000-0002-6732-2691)
- Ana Pozueta‐Cantudo
- Armando Ruiz (ORCID: https://orcid.org/0000-0001-8896-8611)
- María García‐Martínez (ORCID: https://orcid.org/0009-0004-5422-1842)
- Nancy Heidy Cahuana-Santamaría
- Álvaro Nevado-Cáceres
- Andrea Valera‐Barrero
Institutions
- Universidad de Cantabria (ES)
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Marqués de Valdecilla University Hospital (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Global Brain Health Institute (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1186/s13195-025-01719-5
- Citations
- 9
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 13.24