Effect of Agomelatine on Ischemic Damage in Experimental Head Trauma Model in Rats

Objective: This study aims to investigate the effect of agomelatine on ischemic injury in an experimentally created head trauma model in rats. Materials and Methods: Groups: 1) control (C) incisions were made to the coronal and lambdoid sutures and a steel disc was placed without creating a controlled impact acceleration model; 2) head trauma (HT) did not receive any treatment after head trauma with a controlled impact acceleration model; 3) agomelatine (A) 20 mg/kg oral agomelatine given for 7 d after incisions were made to the coronal and lambdoid sutures and a steel disc was placed without creating a controlled impact acceleration model; 4) head trauma+agomelatine (HT-A) 20 mg/kg oral agomelatine given for 7 d after head trauma with a controlled impact acceleration model. The rats were humanely euthanized after the study by ethical protocols, and blood and tissue samples were taken. Biochemical (tumor necrosis factor [TNF]-α and interleukin [IL]-6) and histopathological analyses (terminal deoxynucleotidyl transferase dUTP nick end labeling [TUNEL]) were conducted from these samples. Results: A significant difference was found in TNF-α between the HT and HT-A groups (p