Exosome-transmitted HSPA9 facilitates bortezomib resistance by targeting TRIP13/USP1 signaling in multiple myeloma
Our findings propose a pioneering molecular regulatory network in which MM-cell-derived exosomes HSPA9 transmitted BTZ resistance through the USP1/TRIP13 signaling pathway. This research highlights exosomes HSPA9 as a promising target to overcome MM BTZ resistance.
Authors
- Xuxing Shen (ORCID: https://orcid.org/0000-0003-0110-1463)
- Jiapei Yu
- Na Shen (ORCID: https://orcid.org/0000-0003-4362-9207)
- Min Shi (ORCID: https://orcid.org/0009-0004-0671-4052)
- Yuan Xia (ORCID: https://orcid.org/0000-0002-8061-4955)
- Xiangyu Liu (ORCID: https://orcid.org/0000-0002-1669-9149)
- Ying Chen (ORCID: https://orcid.org/0000-0002-7322-2224)
- Lijuan Chen (ORCID: https://orcid.org/0000-0001-7331-4359)
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12964-025-02158-3
- Citations
- 5
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.85
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province