Associations of combined lifestyle and metabolic risks with cancer incidence in the UK biobank study
MetS elevates risks for multiple cancers, while adopting a healthy lifestyle reduces risks of oesophagus, stomach, and lung, bronchus, trachea cancers in men and lung, bronchus, trachea cancer in women, regardless of metabolic status. However, MetS counteracts lifestyle-mediated protection against specific cancers-including lip, oral cavity, pharynx, colon, rectum, pancreas, kidney, and bladder cancers in men, as well as pancreas and breast cancers in women. These findings underscore the necessity to develop metabolic status-stratified management strategies and implement proactive prevention of MetS.
Authors
- Xin-Ran Tang (ORCID: https://orcid.org/0000-0001-9726-3306)
- Haixiang Zhang (ORCID: https://orcid.org/0000-0002-7311-5605)
- Xianyue Ren (ORCID: https://orcid.org/0000-0002-1845-0814)
- Hong Zhu (ORCID: https://orcid.org/0000-0001-7502-278X)
- Xiao-Hong Hong (ORCID: https://orcid.org/0000-0002-2767-4166)
- Hongfan Chen (ORCID: https://orcid.org/0000-0003-0814-2006)
- Chuanhui Yang (ORCID: https://orcid.org/0009-0002-4084-1966)
- Lin Feng (ORCID: https://orcid.org/0000-0001-6461-5838)
- Binglin Cheng
- Jiaxin Li (ORCID: https://orcid.org/0000-0002-4373-9695)
- Xiang Yuan (ORCID: https://orcid.org/0000-0002-4280-9997)
- Wen Hu (ORCID: https://orcid.org/0009-0005-8698-0920)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Nanfang Hospital (CN)
- Stomatology Hospital (CN)
- Hospital of Stomatology, Sun Yat-sen University
- Southern Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12885-025-13955-x
- Citations
- 2
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province