HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS

This article reviews the development of the asymmetric synthesis of tailor-made amino acids conducted at Hamari Chemicals during the 10-year period 2013–2022.The discussion is based on strategies such as direct chiral modification of unprotected amino acids via intermediate formation of Ni(II) complexes and elaboration of chiral nucleophilic or electrophilic glycine equivalents. The former approach includes, for example, second-order asymmetric transformation, dynamic kinetic resolution, and inversion of chirality while the latter approach involves construction of the desired amino acid architecture using, for example, alkylation, aldol, Mannich, or Michael addition reactions as well as multistep procedures. Operational convenience, scalability, and practicality of the developed methods are emphasized.

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Publication Details

Journal
Ukrainian Chemistry Journal
Published
2024-11-29
DOI
https://doi.org/10.33609/2708-129x.90.10.2024.88-134
Citations
5
Primary Topic
Chemical Synthesis and Analysis
Type
article
Field-Weighted Citation Impact
1.17
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article

HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS

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HAMARI’S CONTRIBUTION TO THE ASYMMETRIC SYNTHESIS OF TAILOR-MADE AMINO ACIDS

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article en
5 citations

Abstract

This article reviews the development of the asymmetric synthesis of tailor-made amino acids conducted at Hamari Chemicals during the 10-year period 2013–2022.The discussion is based on strategies such as direct chiral modification of unprotected amino acids via intermediate formation of Ni(II) complexes and elaboration of chiral nucleophilic or electrophilic glycine equivalents. The former approach includes, for example, second-order asymmetric transformation, dynamic kinetic resolution, and inversion of chirality while the latter approach involves construction of the desired amino acid architecture using, for example, alkylation, aldol, Mannich, or Michael addition reactions as well as multistep procedures. Operational convenience, scalability, and practicality of the developed methods are emphasized.

Ukrainian Chemistry JournalVol. 90(10)
Yamagata University (JP), National Academy of Sciences of Ukraine (UA), Nanjing Forestry University (CN), University of the Basque Country (ES), Jan Kochanowski University (PL), German Cancer Research Center (DE), Chinese Academy of Sciences (CN), Heidelberg University (DE), Shanghai Institute of Materia Medica (CN), Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar (UA), Hamari Chemicals (Japan) (JP), National Institute of Advanced Industrial Science and Technology (JP)
Openalex Percentile: Top 21%
Chemical Synthesis and Analysis
1.17
DOIOpen Access PDFOpenAlex
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