BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease
Individuals with type 2 diabetes who exhibit higher-than-expected serum ferritin levels relative to their BMI may have a lower risk of cardiovascular events. These findings suggest that ferritin may play a more complex role in cardiovascular risk than previously assumed and highlight the potential for refined risk stratification strategies in type 2 diabetes management.
Authors
- Carel Wynand le Roux (ORCID: https://orcid.org/0000-0001-5521-5445)
- Jordi Blanch (ORCID: https://orcid.org/0000-0001-8211-3292)
- Paul W. Franks (ORCID: https://orcid.org/0000-0002-0520-7604)
- Daniel Coral (ORCID: https://orcid.org/0000-0002-8809-4544)
- Geltrude Mingrone (ORCID: https://orcid.org/0000-0003-2021-528X)
- Rafel Ramos (ORCID: https://orcid.org/0000-0001-7970-5537)
- Talita Duarte‐Salles (ORCID: https://orcid.org/0000-0002-8274-0357)
- Yenny Leal (ORCID: https://orcid.org/0000-0003-1926-1844)
- Ewan R. Pearson (ORCID: https://orcid.org/0000-0001-9237-8585)
- José Manuel Fernández‐Real (ORCID: https://orcid.org/0000-0002-7442-9323)
- Laura Gallardo‐Nuell
- Giuseppe N. Giordano
Institutions
- University College Dublin (IE)
- Università Cattolica del Sacro Cuore (IT)
- University of Dundee (GB)
- King's College London (GB)
- Lund University (SE)
- Universitat de Girona (ES)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Erasmus MC (NL)
- Agostino Gemelli University Polyclinic (IT)
- Red de Investigación en Actividades Preventivas y Promoción de la Salud (ES)
- Institut d'Investigació Biomèdica de Girona (ES)
- Institut Universitari d'Investigació en Atenció Primària Jordi Gol (ES)
- Genomics (United Kingdom) (GB)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Hospital Universitari de Girona Doctor Josep Trueta (ES)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12933-025-02685-w
- Citations
- 2
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- European Federation of Pharmaceutical Industries and Associations
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Instituto de Salud Carlos III