Mortality and clinical outcomes of colistin versus colistin-based combination therapy for infections caused by Multidrug-resistant Acinetobacter baumannii in critically ill patients
The study findings demonstrate the benefits of investigated colistin combination options that result in less one-year all-cause mortality, better clinical cure, higher microbiologic response, and less infection recurrence. However, no significant differences were observed regarding 30-day mortality. In addition, the study highlights the limitations of the available antimicrobial options and the crucial need for new effective antimicrobials and more successful combinations.
Authors
- Mashael Alhajri (ORCID: https://orcid.org/0000-0002-9325-0281)
- Bashayer M. AlShehail (ORCID: https://orcid.org/0000-0003-2372-9462)
- Marwan Jabr Alwazzeh (ORCID: https://orcid.org/0000-0002-4646-6717)
- Sara Alwarthan (ORCID: https://orcid.org/0000-0001-5061-8560)
- Amani Alnimr (ORCID: https://orcid.org/0000-0001-5105-6002)
- Jumanah Algazaq (ORCID: https://orcid.org/0000-0003-4774-8975)
- Fahd A Al-Muhanna (ORCID: https://orcid.org/0000-0003-2169-8391)
- Fatimah H. Alsalem
- Faten Hussain Alsaihati
- Fatimah Alabkari
- Ahmad Wajeeh Alrefaai
Institutions
- King Fahd Hospital of the University (SA)
- Imam Abdulrahman Bin Faisal University (SA)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12879-025-10781-1
- Citations
- 6
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 3.55