Early hemodynamic impact of SGLT2 inhibitors in overweight cardiometabolic heart failure: beyond fluid offloading to vascular adaptation– a preliminary report
Early hemodynamic responses to SGLT2i may differ across HF subtypes. In overweight patients with cardiometabolic HFpEF, our preliminary findings suggest an association with reduced vascular resistance, while in HFrEF/HFmrEF, the primary benefit appears to be volume unloading. However, the vascular effects of SGLT2i remain uncertain, and given the small sample size, these results should be interpreted as hypothesis-generating. Our findings also highlight the potential role of non-invasive hemodynamic monitoring in guiding therapy in HF.
Authors
- Nadia Salerno (ORCID: https://orcid.org/0000-0002-1929-2168)
- Giuseppe Armentaro (ORCID: https://orcid.org/0000-0001-9775-9715)
- Assunta Di Costanzo (ORCID: https://orcid.org/0009-0007-9963-6402)
- Sabato Sorrentino (ORCID: https://orcid.org/0000-0002-8316-7134)
- Jessica Ielapi (ORCID: https://orcid.org/0009-0009-8291-284X)
- Angelica Cersosimo (ORCID: https://orcid.org/0000-0001-8463-8412)
- Daniele Torella (ORCID: https://orcid.org/0000-0002-4915-5084)
- Angela Sciacqua (ORCID: https://orcid.org/0000-0003-1674-5317)
- Salvatore De Rosa
- Isabella Leo (ORCID: https://orcid.org/0000-0002-4774-0888)
Institutions
- Magna Graecia University (IT)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12933-025-02699-4
- Citations
- 7
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 9.72
Funders
- Ministero della Salute
- Ministero dell'Università e della Ricerca