Lifespan of male and female APP/PS1 and APP <sup>NL-F/NL-F</sup> mouse models of Alzheimer's disease
Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP<sup>NL-F/NL-F</sup>) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in male APP<sup>NL-F/NL-F</sup> mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.
Authors
- Kevin N. Hascup (ORCID: https://orcid.org/0000-0001-6604-1874)
- Kathleen Quinn
- Andrzej Bartke (ORCID: https://orcid.org/0000-0002-2569-557X)
- Yimin Fang (ORCID: https://orcid.org/0000-0001-9270-5857)
- Erin R. Hascup (ORCID: https://orcid.org/0000-0003-1037-0809)
- Mackenzie R. Peck
- Hannah Roberts
- Tiarra Hill
Institutions
- Southern Illinois University School of Medicine (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1177/13872877251325878
- Citations
- 3
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- National Institute on Aging