Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2
Our studies identified a novel vicious cycle between neutrophils and hepatocytes through the LECT2-PHB2 interaction, presenting a promising therapeutic intervention by targeting LECT2 to mitigate AH in patients.
Authors
- Hongzhuan Yin (ORCID: https://orcid.org/0000-0002-8029-0911)
- Wei Wang (ORCID: https://orcid.org/0000-0001-8388-0987)
- Shiwei Zhu (ORCID: https://orcid.org/0000-0003-1145-1192)
- Haoxiong Zhou (ORCID: https://orcid.org/0000-0002-3781-5241)
- Ming‐Hua Zheng (ORCID: https://orcid.org/0000-0003-4984-2631)
- Jiong Chen (ORCID: https://orcid.org/0000-0001-9389-520X)
- Long Gao (ORCID: https://orcid.org/0000-0002-2631-6914)
- Xutong Li (ORCID: https://orcid.org/0000-0001-9547-0643)
- Yanhang Gao (ORCID: https://orcid.org/0000-0001-8590-6706)
- Suthat Liangpunsakul (ORCID: https://orcid.org/0000-0002-6504-8123)
- Jiangfeng Qin
- Zihao Wu (ORCID: https://orcid.org/0000-0003-0025-0934)
- Yuanru Yang
- Hui Zhang (ORCID: https://orcid.org/0000-0002-6597-8910)
- Hua Wang (ORCID: https://orcid.org/0000-0002-2605-5697)
- Jiabin Li
- Li Zuo (ORCID: https://orcid.org/0000-0002-7887-0335)
- Jinjun Chen (ORCID: https://orcid.org/0000-0003-4275-9149)
- Wenzhe Zhang (ORCID: https://orcid.org/0000-0001-7596-3715)
- Yufeng Gao (ORCID: https://orcid.org/0000-0003-0032-3531)
- Honghai Xu (ORCID: https://orcid.org/0000-0002-3710-8694)
- Jiatao Liu (ORCID: https://orcid.org/0000-0002-2865-1716)
- Tingting Qi (ORCID: https://orcid.org/0000-0001-8400-9456)
- Yuanyuan Wei (ORCID: https://orcid.org/0000-0001-7639-9837)
- Feng Xu (ORCID: https://orcid.org/0000-0002-7827-2319)
Institutions
- Ningbo University (CN)
- University of Science and Technology of China (CN)
- Ministry of Education of the People's Republic of China (CN)
- Sun Yat-sen University (CN)
- Capital Medical University (CN)
- Jilin University (CN)
- Anhui Medical University (CN)
- Wenzhou Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- Nanfang Hospital (CN)
- Beijing Xuanwu Traditional Chinese Medicine Hospital (CN)
- First Hospital of Jilin University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Southern Medical University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1136/gutjnl-2024-334318
- Citations
- 9
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 13.24
Funders
- National Natural Science Foundation of China
- Anhui Provincial Department of Education
- Medical and Health Research Project of Zhejiang Province