APPLICATION OF IMMUNOSTIMULANTS IN COMBINATION WITH ANTIOXIDANTS IN THE COMPREHENSIVE TREATMENT OF PATIENTS WITH ODONTOGENIC PHLEGMONS

The article is a fragment of the complex initiative theme of the Department of Oral and Maxillofacial Surgery of the Poltava State Medical University "Algorithm for the complex treatment of inflammatory processes and prevention of the formation of pathological scars of skin of head and neck after planned and urgent surgical interventions" (state registration number 0124U000093).Introduction.Purulent-inflammatory diseases of the maxillofacial region occupy a significant place in the clinic of surgical dentistry [1].Despite the improvement of diagnostic methods, surgical and conservative treatment, a rapid increase these diseases, an active spread of the purulent process and, as a result, the occurrence of life-threatening complications, such mediastinitis, have now been fixed [2,3,4].It should be noted that today there is also a tendency to increase the number of odontogenic phlegmons, which involve two or more cellular spaces of the head and neck: they are characterized by a long course, lack of correlation between local and general manifestations of the disease and are distinguished by "resistance" to traditional conservative treatment methods [5,6,7,8].Since the elimination of any infectious agent is the result of combined relationships between the protective forces of the macroorganism and microbial agents, the use of only antibiotics with the opening and drainage of the purulent focus is currently insufficiently effective and leads to complications in 12-23% of cases [9,10,11].Therefore, direct or indirect activation and support of