EVALUATION OF HYSTEROSCOPIC AND IMMUNOHISTOCHEMICAL CHANGES IN THE ENDOMETRIUM OF PATIENTS WITH INFERTILITY

Connection of the publication with planned research works.The study was carried out within the framework of the scientific research work "Improving the diagnostics and treatment of pregnant women with a burdened somatic anamnesis" (state registration number 0121U100153). Introduction.The endometrium, the lining of the uterus, plays a critical role in the process of fertilization and maintenance of pregnancy.After fertilization, the egg develops into an embryo that must implant in the uterus to continue its development.To do this, the endometrium must be properly prepared, changing under the influence of hormones.Its structure and thickness determine the possibility of implantation, as well as the subsequent support of the embryo in the early stages of pregnancy.A healthy and functional endometrium is the basis for successful conception and normal development of pregnancy, therefore any disturbances in its development can significantly affect the ability to conceive and the course of pregnancy [1].Chronic endometritis (CE) is an inflammation of the uterine mucosa that can affect a woman's ability to become pregnant.This disease is one of the possible causes of infertility, as it disrupts the function of the endometrium and can complicate embryo implantation [2,3].According to various studies, chronic endometritis occurs in infertile women with varying frequencies, depending on the specifics of the study and diagnostic methods.General data indicate that: In women suffering from infertility and having normal ovulation, chronic endometritis is detected in 5-25% of cases.In women with infertility associated with unknown causes, the frequency of detection of chronic endometritis may be higher and reach 40-50%.In some studies that include women with recurrent miscarriages or implantation failures during assisted reproductive technologies (ART), the frequency of chronic endometritis can reach up to