Colonic mucosal TRPA1 expression profiles in irritable bowel syndrome and its correlation to symptom severity: An exploratory study
These findings suggest a potential role for the TRPA1 related pathway as a target for IBS treatment in the future. Since there was no correlation found in the current exploratory study between TRPA1 expression and symptom severity, further research towards the clinical relevance of the increased TRPA1 expression in IBS-patients along with its location-specific expression is warranted.
Authors
- Ad Masclee (ORCID: https://orcid.org/0000-0001-5819-0116)
- Solveig Skovlund Groen
- Lisa Vork (ORCID: https://orcid.org/0000-0001-7316-3191)
- Zsuzsanna Helyes (ORCID: https://orcid.org/0000-0003-2435-4367)
- Daisy M.A.E. Jonkers (ORCID: https://orcid.org/0000-0001-8981-8965)
- Dániel Keszthelyi (ORCID: https://orcid.org/0000-0001-9856-9980)
- Zsa Zsa R. M. Weerts (ORCID: https://orcid.org/0000-0001-7522-9916)
- Ellen Wilms (ORCID: https://orcid.org/0000-0001-7146-8581)
- Pan Xu
- Montserrat Elizalde
- Justin Huig
Institutions
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- University of Pecs (HU)
Publication Details
- Journal
- Autonomic Neuroscience
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1016/j.autneu.2025.103273
- Citations
- 2
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.62
Funders
- Nemzeti Kutatási, Fejlesztési és Innovaciós Alap