Complete blood count based on microfluidics and dielectrophoretic force separation

A Complete Blood Count (CBC) routine blood test gives vital details on the kinds and quantities of Red Blood Cells (RBCs), White Blood Cells (WBCs), and platelets (PLT) in the blood. Microfluidic devices are designed with specific channel geometries and features that exploit blood cells' differences in size and deformability. Using a microfluidic chip, this device aims to develop optimization techniques for separating PLTs and WBCs from RBCs. The design and analysis were carried out using the COMSOL Multiphysics program. The Dielectrophoretic force technique is crucial for separating PLTs, WBCs, and RBCs by manipulation of their flow. Data analysis revealed that voltage applied and blood inlet velocity affect fluidic velocity and pressure. The separation of blood components mainly depends on input data. To separate all main blood cells, the software is used to create efficient microfluidic channels. The pressure, velocity, and distribution effect of each cell about the applied voltage and the fluid's inlet velocity during the analysis process of the proposed microfluidic were detected and resulted in the successful separation of RBCs from WBCs and PLTs.