Frequency to Anti-HBS Antibody Sero-Positivity (> 10 mIU/ml) in Children Aged 5-10 Years after Hepatitis B Vaccination in Infancy

Objective: To determine the frequency of anti-Hepatitis B Surface antibody (anti-HBS antibody) seropositivity (> 10 mIU/ml) in 5-10 years old children after hepatitis B vaccination during infancy.Study Design: Cross-sectional study. Place and Duration of Study: This study was conducted in the Pediatrics Department, Combined Military Hospital (CMH) Rawalpindi, Pakistan, from 16th May 2020 to 16th November 2020.Methods: Patients aged 5-10 years, irrespective of gender, and who completed vaccination of hepatitis B during infancy were included in this study. Parents of patients who refused to consent and were without complete immunization of hepatitis B during infancy were excluded. Blood samples were taken for anti-HBS antibody titer. Patients with anti-HBS antibody levels > 10 mIU/ml were considered to have a positive response to vaccination. The patients whose anti-HBS titer was < 10 mIU/ml were considered to have the negative response to immunization against hepatitis B. Data were entered using the proforma.Results: A total of 343 cases were enrolled. The mean age was 7.46 ± 1.80 years (minimum was five and maximum was 10 years). About 47.8 % of cases had titer less than 10, 43.1 % had equal to or more than 10, and 9 % had Titer equal to or more than 100. 52.2 % had immune status positive, and 47.8 had negative status.Conclusion: Although the majority of our cases were immune to HBV infection, the difference was only minor compared to the numbers in the non-immune group. After EPI vaccination, the immune status was found to be more retained in the females than in the males. How to cite this: Aziz A, Tabussam S, Iqbal A, Jabbar G, Hussain S, Shahid H. Frequency to Anti-HBS Antibody Sero-Positivity (> 10 mIU/ml) in Children Aged 5-10 Years after Hepatitis B Vaccination in Infancy. Life and Science. 2025; 6(1): 10-14. doi: http://doi.org/10.37185/LnS.1.1.496