Rationale and Study Design to Assess the Efficacy and Safety of Minocycline in Patients with Moderate to Severe Acute Ischaemic Stroke (EMPHASIS)
The EMPHASIS trial is the first phase III trial to investigate whether minocycline is effective and safe in improving functional outcome at 90 days in patients with moderate-to-severe acute ischaemic stroke. The data generated may provide valuable evidence of a potential anti-inflammation treatment for ischaemic stroke.
Authors
- Baoshan Qiu
- Xuejiao Zhou (ORCID: https://orcid.org/0000-0002-4613-3349)
- Hui Qu (ORCID: https://orcid.org/0000-0003-4809-570X)
- Y. Wang (ORCID: https://orcid.org/0000-0002-0271-626X)
- Dongyang Zhou
- Luyan Wang (ORCID: https://orcid.org/0000-0002-8632-9573)
- Xiaoling Liao (ORCID: https://orcid.org/0000-0003-4620-9224)
- Philip M. Bath (ORCID: https://orcid.org/0000-0003-2734-5132)
- Yuesong Pan (ORCID: https://orcid.org/0000-0003-3082-6789)
- Liping Liu (ORCID: https://orcid.org/0000-0003-2943-055X)
- Xingquan Zhao (ORCID: https://orcid.org/0000-0001-8345-5147)
- Yilong Wang (ORCID: https://orcid.org/0000-0002-3267-0039)
- Ling Guan (ORCID: https://orcid.org/0000-0003-3381-8370)
- Qianqian Yang (ORCID: https://orcid.org/0000-0002-3970-0093)
- Meiyang Zhang
- Yao Lu (ORCID: https://orcid.org/0000-0003-1048-1066)
- Pierre Amarenco
- S. Claiborne Johnston
- Yongjun Wang (ORCID: https://orcid.org/0000-0002-1796-5576)
Institutions
- University of British Columbia (CA)
- University of Nottingham (GB)
- Capital Medical University (CN)
- Population Health Research Institute (CA)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Sorbonne Paris Cité (FR)
- Chinese Institute for Brain Research (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- The University of Texas at Austin (US)
- McMaster University (CA)
Publication Details
- Journal
- Stroke and Vascular Neurology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1136/svn-2024-003577
- Citations
- 3
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China