Human Efficacy Evaluation Study on the Reduction of Calf Swelling, Improvement of Blood Circulation, and Increase in Skin Temperature of a Patch Product Containing Derma Genie™ and Elixir Stone™

Purpose: This study evaluated the human efficacy of a patch product formulated with the active ingredients Derma Genie™ and Elixir Stone™ in reducing calf swelling, improving blood circulation, and increasing skin temperature (thermogenic effect). Methods: A human application test was conducted for 4 weeks on 20 adult female participants aged 20–60 years to assess the effects of the patch product on the three variables mentioned above. Results: The evaluation of calf swelling demonstrated a statistically significant decrease in swelling compared with that in the untreated area (p<0.05). In the assessment of blood circulation, the rate of change in the patch-applied area was significantly higher, confirming its beneficial effect of enhancing circulation (p<0.05). Finally, the skin temperature evaluation showed a statistically significant increase of 6.84% in the patch-applied area after a single application compared with the baseline, supporting its immediate thermogenic effect (p<0.05). Conclusion: These findings confirm that the patch product formulated with the active ingredients Derma Genie™ and Elixir Stone™ is effective at reducing calf swelling, improving blood circulation, and increasing skin temperature.