Myelopathic motor symptoms overlaying Parkinson’s disease

Parkinson's disease (PD) may increase the risk of degenerative cervical myelopathy, causing overlaying myelopathic motor symptoms that can be challenging to identify. However, this diagnosis must not be missed, given the risk of profound and lasting disability and the benefit of surgical intervention. We describe a fortnight in which three patients with PD were admitted to our inpatient movement disorders service with degenerative cervical myelopathy; each highlighting a distinct learning point regarding diagnosis or management. First, that careful examination is crucial, and clinicians should always consider degenerative cervical myelopathy in a patient with PD whose mobility has dramatically reduced. Second, patients may need pharmacological suppression of cervical dyskinesias after surgery to prevent ongoing injury and to promote healing. Third, medical factors, such as B12 deficiency, with the potential to exacerbate myelopathic effects, should be corrected.

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Publication Details

Journal
Practical Neurology
Published
2025-03-26
DOI
https://doi.org/10.1136/pn-2025-004546
Primary Topic
Cervical and Thoracic Myelopathy
Type
article
Field-Weighted Citation Impact
0.00

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article

Myelopathic motor symptoms overlaying Parkinson’s disease

James E. Groves, Anouk Borg, Thomas Foltynie, Patricia Limousin et al.
Practical Neurology
Cervical and Thoracic Myelopathy
article

Myelopathic motor symptoms overlaying Parkinson’s disease

James E. Groves, Anouk Borg, Thomas Foltynie, Patricia Limousin, Arpan R. Mehta, L.V. Prasad Korlipara, Demot H Mallon, Nathalie Zaidman
article en

Abstract

Parkinson's disease (PD) may increase the risk of degenerative cervical myelopathy, causing overlaying myelopathic motor symptoms that can be challenging to identify. However, this diagnosis must not be missed, given the risk of profound and lasting disability and the benefit of surgical intervention. We describe a fortnight in which three patients with PD were admitted to our inpatient movement disorders service with degenerative cervical myelopathy; each highlighting a distinct learning point regarding diagnosis or management. First, that careful examination is crucial, and clinicians should always consider degenerative cervical myelopathy in a patient with PD whose mobility has dramatically reduced. Second, patients may need pharmacological suppression of cervical dyskinesias after surgery to prevent ongoing injury and to promote healing. Third, medical factors, such as B12 deficiency, with the potential to exacerbate myelopathic effects, should be corrected.

Practical NeurologyVol. 25(5)
University College London Hospitals NHS Foundation Trust (GB), University of Dundee (GB), MRC Protein Phosphorylation and Ubiquitylation Unit (GB), UK Dementia Research Institute (GB), National Hospital for Neurology and Neurosurgery (GB), University College London (GB)
Alzheimer's Research Trust, Medical Research Council
Good health and well-being
Openalex Percentile: Top 90%
Cervical and Thoracic Myelopathy
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