Cancer-Associated Fibroblasts Foster a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer
Targeting cancer-associated fibroblast metabolism or histone lactylation in pancreatic cancer cells to reverse epigenetic remodeling induced by lactate accumulation in the tumor microenvironment are potential therapeutic strategies to inhibit perineural invasion.
Authors
- Di Cheng (ORCID: https://orcid.org/0009-0009-7791-4760)
- Rufu Chen (ORCID: https://orcid.org/0009-0009-7422-5222)
- Huimou Chen
- Chonghui Hu (ORCID: https://orcid.org/0000-0001-9305-9834)
- Rihua He
- Jiang Yong (ORCID: https://orcid.org/0000-0001-8495-4474)
- Tianhao Huang
- Honghui Jiang
- Kaijun Huang
- Yu Zhou (ORCID: https://orcid.org/0000-0003-3990-0308)
- Shangyou Zheng (ORCID: https://orcid.org/0009-0008-0528-9014)
- Qing Tian (ORCID: https://orcid.org/0000-0002-2183-2012)
- Tingting Li (ORCID: https://orcid.org/0009-0003-4233-0702)
- Yuan Yuan (ORCID: https://orcid.org/0000-0003-4809-8759)
Institutions
- Sun Yat-sen University (CN)
- Guangdong General Hospital (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3173
- Citations
- 35
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 56.89