СLINICAL CASE OF FABRY DISEASE

caffeine effect on echocardiographic parameters in an experimental model of doxorubicin-induced cardiomyopathy in female rats to explore its potential cardioprotective effect and its role in regulating the autonomic nervous system.The study involved 36 white sexually mature female rats, which were randomly divided into three groups (12 animals per group): Group I -control group of female rats receiving saline (1 mg/kg) via gastric gavage, Group II -group of female rats treated with 1 mg/kg of doxorubicin via gastric gavage, Group III -group of female rats treated with caffeine (25 mg/kg per day) and doxorubicin (1 mg/kg) administered intragastrically.Echocardiography was performed using the MyLab Gamma ultrasound system by Esaote with a linear transducer (SL 3235).The results indicate that doxorubicin causes the DICM development, while caffeine exerts a pronounced cardioprotective effect, preventing the deterioration of heart function.These findings may be of significant value for future studies exploring the use of caffeine and its derivatives for myocardial protection during doxorubicin-based chemotherapy.