CARDIO-RENAL-METABOLIC SYNDROME CHARACTERISTICS IN PATIENTS WITH CHRONIC FORMS OF ISCHEMIC HEART DISEASECARDIO-RENAL-METABOLIC SYNDROME CHARACTERISTICS IN PATIENTS WITH CHRONIC FORMS OF ISCHEMIC HEART DISEASE

Currently, ischemic heart disease (IHD) holds a leading position among the pressing healthcare issues, as its course is associated with the development of life-threatening complications.The comorbidity of IHD with arterial hypertension (AHT) and irritable bowel syndrome (IBS) with their numerous common risk factors and pathogenic mechanisms, may be characterized by additional neurovegetative and metabolic imbalances, while also exhibiting distinct clinical symptoms.The aim of the study was to identify the clinical features of arterial hypertension in patients with IHD combined with IBS.Object and research methods.A total of 112 patients aged 39 to 68 years with ischemic heart disease and hypertensive disease were observed.In 52 patients (46.4%),IHD and arterial hypertension were combined with IBS.Additionally, 60 patients with isolated IBS were examined.For thorough risk stratification, all selected patients with IHD had stable ischemic heart disease (SIHD).Results.A higher frequency of chest pain occurrence and radiation was observed, with a predominance of aching and pressing pain over sharp and burning pain in patients (p<0.01).Patients with SIHD and AHT combined with IBS reported a greater variety and frequency of complaints compared to those without IBS.The pathogenesis of the main complaints indicates the significant role of autonomic nervous system imbalance in the development of arterial hypertension in these patients.Individuals with SIHD and AHT with IBS exhibited increased daytime and nighttime systolic (SBP) and diastolic blood pressure (DBP), which serve as unfavorable predictors of cardiovascular complications.Increased blood pressure variability and the absence of adequate nocturnal dipping in SBP, which may lead to target organ damage, were also detected in patients with SIHD and AHT with IBS.Conclusions.In patients with SIHD and AHT combined with IBS, a number of clinical and pathogenic features of arterial hypertension were identified, affecting the patient's condition and the risk of complications.The presence of IBS in patients with IHD and AHT intensified the course of hypertension, contributing to its rapid progression.