BRCA1 regulates glucose and lipid metabolism in diabetes mellitus with metabolic dysfunction-associated steatotic liver disease via the PI3K/Akt signaling pathway
As a key regulator of hepatocyte metabolism under HG conditions, BRCA1 can participate in regulating glucose and lipid metabolism in mouse primary hepatocytes through the PI3K/AKT signaling pathway, which be able to become a possible remedy strategy for DM with MASLD.
Authors
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Cui Ma
- Xiaodi Yang (ORCID: https://orcid.org/0000-0002-7411-5797)
- Liyin Zhang (ORCID: https://orcid.org/0000-0002-9165-0708)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-1924-0325)
- Y. H. Zhang
Institutions
- East China University of Science and Technology (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Chest Hospital (CN)
- First People's Hospital of Yuhang District (CN)
- Minhang District Central Hospital (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1371/journal.pone.0318696
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06