Phase I, First-in-Human Study of FOR46 (FG-3246), an Immune-Modulating Antibody-Drug Conjugate Targeting CD46, in Patients With Metastatic Castration-Resistant Prostate Cancer
FOR46 demonstrated encouraging preliminary clinical activity with a manageable safety profile. Targeting CD46 elicited an immune priming effect that was associated with clinical outcomes.
Authors
- Elisabeth I. Heath (ORCID: https://orcid.org/0000-0003-1381-2713)
- Eric Jay Small (ORCID: https://orcid.org/0000-0003-3191-6268)
- Andrew Dorr
- Jiaoti Huang (ORCID: https://orcid.org/0000-0003-1195-1998)
- Alexander Cheung (ORCID: https://orcid.org/0000-0002-2115-6966)
- Marc Nasoff
- John Hunter (ORCID: https://orcid.org/0000-0001-8262-4404)
- David A. Quigley (ORCID: https://orcid.org/0000-0002-4726-1473)
- Matthew B. Rettig (ORCID: https://orcid.org/0000-0002-7394-3056)
- Jill Abbey
- Adam Foye (ORCID: https://orcid.org/0000-0002-9910-9836)
- Lawrence H. Fong (ORCID: https://orcid.org/0000-0002-6428-428X)
- David James VanderWeele (ORCID: https://orcid.org/0000-0003-4576-5034)
- Arun K. Chumber (ORCID: https://orcid.org/0009-0004-8247-437X)
- Rahul Aggarwal (ORCID: https://orcid.org/0000-0001-7003-7982)
- Robert R. Flavell (ORCID: https://orcid.org/0000-0002-8694-1199)
- Jacqueline Vuky (ORCID: https://orcid.org/0000-0001-5795-3361)
- Stanley G. Leung (ORCID: https://orcid.org/0000-0001-9470-8760)
- Bin Liu (ORCID: https://orcid.org/0000-0002-0956-2777)
- Steven Wang (ORCID: https://orcid.org/0000-0002-5019-5024)
Institutions
- Northwestern University (US)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- Duke University (US)
- University of California, San Francisco (US)
- Wayne State University (US)
- Fred Hutch Cancer Center (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Los Angeles Medical Center (US)
- Phusis Therapeutics (United States) (US)
- FibroGen (United States) (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1200/jco-24-01989
- Citations
- 9
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 13.67