Verrucous squamous cell carcinoma arising in necrobiosis lipoidica in a young woman

Necrobiosis lipoidica (NL) is a chronic granulomatous degenerative disease, presenting clinically as yellow-brown plaques with central atrophy and elevated violaceous borders.1,2 The condition shows a 3:1 female-to-male ratio and most commonly affects the pretibial region.1,3 NL is classically associated with diabetes mellitus, accounting for 11% to 85% of NL cases, with onset typically in the third decade for type 1 and the fourth decade for type 2 diabetes.3,4 Despite this association, the incidence of NL among individuals with diabetes is low, affecting only 0.3% to 1.2% of this population.

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Publication Details

Journal
JAAD Case Reports
Published
2025-03-26
DOI
https://doi.org/10.1016/j.jdcr.2025.03.007
Primary Topic
Skin Diseases and Diabetes
Type
article
Field-Weighted Citation Impact
0.00

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article

Verrucous squamous cell carcinoma arising in necrobiosis lipoidica in a young woman

Jesse W. Currier, Bryan Daines, George J. Murakawa, Jeremy A. Grekin et al.
1 links
JAAD Case Reports
Skin Diseases and Diabetes
article

Verrucous squamous cell carcinoma arising in necrobiosis lipoidica in a young woman

Jesse W. Currier, Bryan Daines, George J. Murakawa, Jeremy A. Grekin, Chiara Rosenbaum
article en

Abstract

Necrobiosis lipoidica (NL) is a chronic granulomatous degenerative disease, presenting clinically as yellow-brown plaques with central atrophy and elevated violaceous borders.1,2 The condition shows a 3:1 female-to-male ratio and most commonly affects the pretibial region.1,3 NL is classically associated with diabetes mellitus, accounting for 11% to 85% of NL cases, with onset typically in the third decade for type 1 and the fourth decade for type 2 diabetes.3,4 Despite this association, the incidence of NL among individuals with diabetes is low, affecting only 0.3% to 1.2% of this population.

JAAD Case ReportsVol. 60
Central Michigan University (US), Oakland University (US), Beaumont Health (US), Royal Oak Community Coalition (US), Beaumont Hospital (US), Somerset Skin Centre (US), Michigan State University (US)
Amgen, Bristol-Myers Squibb, Pfizer, Astellas Pharma US, Sanofi, Regeneron Pharmaceuticals, Valeant Pharmaceuticals International, Kiniksa Pharmaceuticals, Incyte, Castle Biosciences, Astellas Pharma, Galderma, Sanofi Genzyme, Janssen Pharmaceuticals
Gender equality
Openalex Percentile: Top 88%
Skin Diseases and Diabetes
DOIOpen Access PDFOpenAlex
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Verrucous squamous cell carcinoma arising in necrobiosis lipoidica in a young woman — Jesse W. Currier, Bryan Daines, et al. · JAAD Case Reports (2025) | TGRS Research Map | TGRS