Using Bundled Interventions to Improve Health Outcomes for Black Cisgender and Transgender Women: Findings From the Black Women First Initiative

<b>Objectives.</b> To examine the effects of replicating a bundled package of evidence-informed interventions on social determinants, HIV health outcomes, and health-related quality of life (HRQoL) for 697 Black cisgender and transgender women with HIV across 12 US sites from 2021 to 2023. <b>Methods.</b> Women participated in a minimum of 2 interventions. We collected self-reported HRQoL and social determinants via interview at baseline, 6 months, and 12 months. We collected retention in care and viral suppression via medical chart review. We examined effects by gender identity and type and number of bundled interventions received. <b>Results.</b> In the 12-month postenrollment period, 85.0% of women reached viral suppression and 74.3% were retained in care. Social determinants and HRQoL improved over time. Transgender women had significantly lower odds of retention in care compared with cisgender women (adjusted odds ratio = 0.85; 95% confidence interval = 0.77, 0.93) but an overall higher physical HRQoL score (46.8 vs 40.8). Viral suppression and mental HRQoL did not differ by gender identity. <b>Conclusions.</b> Using a bundled intervention is a promising approach to reach and provide culturally relevant care for Black women with HIV. (<i>Am J Public Health</i>. 2025;115(S1):S46-S56. https://doi.org/10.2105/AJPH.2025.308019).