Effects of sleeve gastrectomy and Roux-en-Y gastric bypass on the pharmacokinetics of gabapentin and pregabalin: A cohort study
Postoperative pharmacokinetic changes for gabapentin were minimal, but for pregabalin we observed more pronounced changes, particularly in one patient. Due to few cases, the results should be interpreted with caution. Given the large inter-individual variation, therapeutic drug monitoring could be considered to capture pharmacokinetic changes and guide dose adjustments postoperatively.
Authors
- Hege‐Merete Krabseth (ORCID: https://orcid.org/0009-0001-9342-582X)
- Olav Spigset (ORCID: https://orcid.org/0000-0001-7902-9014)
- Magnus Strømmen (ORCID: https://orcid.org/0000-0002-4686-0263)
- Arne Helland (ORCID: https://orcid.org/0000-0002-9373-1253)
- Georgios Schoretsanitis (ORCID: https://orcid.org/0000-0002-3851-4117)
Institutions
- Northwell Health (US)
- University of Zurich (CH)
- Norwegian University of Science and Technology (NO)
- University Hospital of Zurich (CH)
- St Olav's University Hospital (NO)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Zucker Hillside Hospital (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1371/journal.pone.0319912
- Citations
- 1
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 2.01