Assessment of functionalized superparamagnetic iron oxide nanoparticles on in vivo multispecies biofilm disease models

Iron oxide nanoparticles (IONPs) are attractive materials for biomedical applications, due to their antimicrobial, anti-inflammatory, and protective properties. They also tend to exhibit higher biocompatibility than other nanoparticles. They can be remotely manipulated to scrub, be directed below the gumline, in and around orthodontic wires and devices, or produce heat when exposed to an external magnetic field. Therefore, the incorporation of IONPs into toothpastes and mouthwashes is beneficial to the overall health of the mouth, could treat dysbiosis, prevent dental decay, and reduce inflammation at the gingival epithelium. We found that maintaining a small hydrodynamic diameter is crucial to maximize antibiofilm effects. Studies show that the antimicrobial properties of nanoparticles increase with smaller particle size. We report on the performance of optimized IONPs a murine model of disease using a multispecies biofilm.

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Publication Details

Published
2025-03-26
DOI
https://doi.org/10.1117/12.3058134
Primary Topic
Blood properties and coagulation
Type
article
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article

Assessment of functionalized superparamagnetic iron oxide nanoparticles on in vivo multispecies biofilm disease models

Kimberly J. Lopez, Leisha M. Armijo, Kayla Simpson, Frauke Seemann et al.
Blood properties and coagulation
article

Assessment of functionalized superparamagnetic iron oxide nanoparticles on in vivo multispecies biofilm disease models

Kimberly J. Lopez, Leisha M. Armijo, Kayla Simpson, Frauke Seemann, Mark A. Newton, Qixu Zhang, P. David Rogers, Marek Osiński, Shayden Fritz, Heloísa D’Ávila, Charles P. Easterling, Jian Sheng, Wei Xu, Chi Huang, Kaitlin Garcia, Megan Escochea
article en

Abstract

Iron oxide nanoparticles (IONPs) are attractive materials for biomedical applications, due to their antimicrobial, anti-inflammatory, and protective properties. They also tend to exhibit higher biocompatibility than other nanoparticles. They can be remotely manipulated to scrub, be directed below the gumline, in and around orthodontic wires and devices, or produce heat when exposed to an external magnetic field. Therefore, the incorporation of IONPs into toothpastes and mouthwashes is beneficial to the overall health of the mouth, could treat dysbiosis, prevent dental decay, and reduce inflammation at the gingival epithelium. We found that maintaining a small hydrodynamic diameter is crucial to maximize antibiofilm effects. Studies show that the antimicrobial properties of nanoparticles increase with smaller particle size. We report on the performance of optimized IONPs a murine model of disease using a multispecies biofilm.

University of Vermont (US), The University of Texas MD Anderson Cancer Center (US), University of New Mexico (US), Texas A&M University (US), Texas A&M University – Corpus Christi (US)
Openalex Percentile: Top 91%
Blood properties and coagulation
DOISourceOpenAlex
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