Prevalence of subpatent Plasmodium falciparum infections in regions with varying transmission intensities and implications for malaria elimination in Mainland Tanzania
Even in very low transmission settings, the prevalence of subpatent infections was 13%, and in low transmission settings it was even higher at 29.4%, suggesting a substantial reservoir that is likely to perpetuate transmission but can be missed by routine malaria case management strategies. Thus, control and elimination programmes may benefit from adoption of more sensitive detection methods to ensure that a higher proportion of subpatent infections are detected.
Authors
- Sijenunu Aaron (ORCID: https://orcid.org/0009-0008-0793-3782)
- Filbert Francis (ORCID: https://orcid.org/0000-0003-1000-4729)
- David Giesbrecht (ORCID: https://orcid.org/0000-0003-2498-4705)
- Rashid A. Madebe
- Julie Gutman (ORCID: https://orcid.org/0000-0001-6769-7322)
- Samwel Lazaro
- Abdallah Lusasi
- Jeffrey A. Bailey (ORCID: https://orcid.org/0000-0002-6899-8204)
- Doris Mbata (ORCID: https://orcid.org/0000-0003-1160-0784)
- Beatus M. Lyimo
- Ruth B. Mbwambo (ORCID: https://orcid.org/0000-0002-1089-1236)
- Zachary R. Popkin-Hall (ORCID: https://orcid.org/0000-0002-8308-5294)
- Daniel Mbwambo (ORCID: https://orcid.org/0009-0001-1089-2482)
- Dativa Pereus (ORCID: https://orcid.org/0000-0003-2813-1312)
- Daniel P. Challe (ORCID: https://orcid.org/0000-0002-6009-4649)
- Deus S. Ishengoma (ORCID: https://orcid.org/0000-0003-2040-3416)
- Rule Budodo (ORCID: https://orcid.org/0000-0003-0297-9219)
- Jonathan J. Juliano (ORCID: https://orcid.org/0000-0002-0591-0850)
- Catherine Bakari (ORCID: https://orcid.org/0000-0002-8710-1765)
- Celine I. Mandara (ORCID: https://orcid.org/0000-0003-4317-4425)
- Salehe S. Mandai (ORCID: https://orcid.org/0009-0001-8088-8761)
- Angelina J. Kisambale (ORCID: https://orcid.org/0009-0002-6913-6558)
- Gervas A. Chacha
- Misago Seth (ORCID: https://orcid.org/0000-0002-7728-7981)
- Ramadhani Moshi
Institutions
- University of North Carolina at Chapel Hill (US)
- Centers for Disease Control and Prevention (US)
- Muhimbili University of Health and Allied Sciences (TZ)
- African Malaria Network Trust (TZ)
- Brown University (US)
- Connecticut Agricultural Experiment Station (US)
- Kampala International University in Tanzania (TZ)
- National Institute for Medical Research (TZ)
- Nelson Mandela African Institution of Science and Technology (TZ)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12936-025-05341-6
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Bill and Melinda Gates Foundation