Neuronal CD47 induces behavioral alterations and ameliorates microglial synaptic pruning in wild-type and Alzheimer’s mouse models
Our study provides evidence that neuronal CD47 overexpression results in synaptic pruning defects and is involved in the pathogenesis of ASD, while also playing a beneficial role in mitigating excessive synaptic loss in Alzheimer's disease.
Authors
- Mengting Chen (ORCID: https://orcid.org/0000-0001-6001-9270)
- Yuxue Lin
- Yuping Ye (ORCID: https://orcid.org/0000-0002-3116-9410)
- Li Sun (ORCID: https://orcid.org/0000-0002-2330-6622)
- Xingqi Wu (ORCID: https://orcid.org/0000-0003-0646-1353)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6415-7005)
- Wei Wang
- Wei Hu (ORCID: https://orcid.org/0000-0003-3137-661X)
- Yujie Cheng
- Yin Xu
- Wei Shao (ORCID: https://orcid.org/0000-0002-8554-7245)
- Panpan Hu
- Shanshan Zhou (ORCID: https://orcid.org/0000-0002-2984-6435)
Institutions
- Anhui University (CN)
- Anhui Medical University (CN)
- Anhui Transport Consulting & Design Institute (China) (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Anhui Mental Health Center (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13578-025-01378-x
- Citations
- 8
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.74
Funders
- National Natural Science Foundation of China